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A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR

Identifieur interne : 003C57 ( Main/Exploration ); précédent : 003C56; suivant : 003C58

A certified plasmid reference material for the standardisation of BCR–ABL1 mRNA quantification by real-time quantitative PCR

Auteurs : H. White [Royaume-Uni] ; L. Deprez [Belgique] ; P. Corbisier [Belgique] ; V. Hall [Royaume-Uni] ; F. Lin [Royaume-Uni] ; S. Mazoua [Belgique] ; S. Trapmann [Belgique] ; A. Aggerholm [Danemark] ; H. Andrikovics [Hongrie] ; S. Akiki [Royaume-Uni] ; G. Barbany [Suède] ; N. Boeckx [Belgique] ; A. Bench [Royaume-Uni] ; M. Catherwood [Royaume-Uni] ; J-M Cayuela [France] ; S. Chudleigh [Royaume-Uni] ; T. Clench [Royaume-Uni] ; D. Colomer [Espagne] ; F. Daraio [Italie] ; S. Dulucq [France] ; J. Farrugia [Royaume-Uni] ; L. Fletcher [Australie] ; L. Foroni [Royaume-Uni] ; R. Ganderton [Royaume-Uni] ; G. Gerrard [Royaume-Uni] ; E. Gineikien [Lituanie] ; S. Hayette [France] ; H. El Housni [Belgique] ; B. Izzo [Italie] ; M. Jansson [Suède] ; P. Johnels [Suède] ; T. Jurcek [République tchèque] ; V. Kairisto [Finlande] ; A. Kizilors [Royaume-Uni] ; D-W Kim [Corée du Sud] ; T. Lange [Allemagne] ; T. Lion [Autriche] ; K M Polakova [République tchèque] ; G. Martinelli [Italie] ; S. Mccarron [Irlande (pays)] ; P A Merle [Pays-Bas] ; B. Milner [Royaume-Uni] ; G. Mitterbauer-Hohendanner [Autriche] ; M. Nagar [Israël] ; G. Nickless [Royaume-Uni] ; J. Nomdedéu [Espagne] ; D A Nymoen [Norvège] ; E O Leibundgut [Suisse] ; U. Ozbek [Turquie] ; T. Paji [Slovénie] ; H. Pfeifer [Allemagne] ; C. Preudhomme [France] ; K. Raudsepp [Estonie] ; G. Romeo [Australie] ; T. Sacha [Pologne] ; R. Talmaci [Roumanie] ; T. Touloumenidou [Grèce] ; V H J. Van Der Velden [Pays-Bas] ; P. Waits [Royaume-Uni] ; L. Wang [Royaume-Uni] ; E. Wilkinson [Royaume-Uni] ; G. Wilson [Royaume-Uni] ; D. Wren [Royaume-Uni] ; R. Zadro [Croatie] ; J. Ziermann [Allemagne] ; K. Zoi [Grèce] ; M C Müller [Allemagne] ; A. Hochhaus [Allemagne] ; H. Schimmel [Belgique] ; N C P. Cross [Royaume-Uni] ; H. Emons [Belgique]

Source :

RBID : PMC:4320294

Descripteurs français

English descriptors

Abstract

Serial quantification of BCR–ABL1 mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of BCR–ABL1 (e14a2 mRNA fusion), BCR and GUSB transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 106, 1.08±0.11 × 105, 1.03±0.10 × 104, 1.02±0.09 × 103, 1.04±0.10 × 102 and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63 BCR–ABL1 testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2 BCR–ABL1 and three control genes (ABL1, BCR and GUSB). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (https://ec.europa.eu/jrc/en/reference-materials/catalogue/; CRM code ERM-AD623a-f).


Url:
DOI: 10.1038/leu.2014.217
PubMed: 25036192
PubMed Central: 4320294


Affiliations:

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Le document en format XML

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<institution>Faculty of Medicine, University of Southampton</institution>
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<name sortKey="Deprez, L" sort="Deprez, L" uniqKey="Deprez L" first="L" last="Deprez">L. Deprez</name>
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<name sortKey="Corbisier, P" sort="Corbisier, P" uniqKey="Corbisier P" first="P" last="Corbisier">P. Corbisier</name>
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<name sortKey="Hall, V" sort="Hall, V" uniqKey="Hall V" first="V" last="Hall">V. Hall</name>
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<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
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<name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name>
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<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
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<country xml:lang="fr">Royaume-Uni</country>
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<nlm:aff id="aff2">
<institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Mazoua, S" sort="Mazoua, S" uniqKey="Mazoua S" first="S" last="Mazoua">S. Mazoua</name>
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<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
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<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Trapmann, S" sort="Trapmann, S" uniqKey="Trapmann S" first="S" last="Trapmann">S. Trapmann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
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</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Aggerholm, A" sort="Aggerholm, A" uniqKey="Aggerholm A" first="A" last="Aggerholm">A. Aggerholm</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Department of Haematology, Aarhus University Hospital</institution>
, Aarhus,
<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Hungarian National Blood Transfusion Service</institution>
, Budapest,
<country>Hungary</country>
</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust</institution>
, Birmingham,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Barbany, G" sort="Barbany, G" uniqKey="Barbany G" first="G" last="Barbany">G. Barbany</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Molecular Medicine and Surgery, Clinical Genetics Karolinska Institutet</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>Department of Laboratory Medicine</institution>
, UZ Leuven,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Department of Oncology, KU</institution>
Leuven,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Bench, A" sort="Bench, A" uniqKey="Bench A" first="A" last="Bench">A. Bench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Catherwood, M" sort="Catherwood, M" uniqKey="Catherwood M" first="M" last="Catherwood">M. Catherwood</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Haematology Department, Belfast City Hospital</institution>
, Belfast,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J-M" last="Cayuela">J-M Cayuela</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Haematology Laboratory and EA3518, University Hospital Saint-Louis, AP-HP, University Paris Diderot</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chudleigh, S" sort="Chudleigh, S" uniqKey="Chudleigh S" first="S" last="Chudleigh">S. Chudleigh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Department of Molecular Haematology, Yorkhill NHS Trust</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Clench, T" sort="Clench, T" uniqKey="Clench T" first="T" last="Clench">T. Clench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">Molecular Haematology, Bristol Royal Infirmary, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Haematology, Bristol Royal Infirmary, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff15">Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name>
<affiliation wicri:level="3">
<nlm:aff id="aff16">Department of Clinical and Biological Science, University of Turin, Turin, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical and Biological Science, University of Turin, Turin</wicri:regionArea>
<placeName>
<settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name>
<affiliation wicri:level="3">
<nlm:aff id="aff17">Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Farrugia, J" sort="Farrugia, J" uniqKey="Farrugia J" first="J" last="Farrugia">J. Farrugia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">Combined Laboratories, Derriford Hospital, Plymouth, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Combined Laboratories, Derriford Hospital, Plymouth</wicri:regionArea>
<wicri:noRegion>Plymouth</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fletcher, L" sort="Fletcher, L" uniqKey="Fletcher L" first="L" last="Fletcher">L. Fletcher</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Foroni, L" sort="Foroni, L" uniqKey="Foroni L" first="L" last="Foroni">L. Foroni</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ganderton, R" sort="Ganderton, R" uniqKey="Ganderton R" first="R" last="Ganderton">R. Ganderton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gineikien, E" sort="Gineikien, E" uniqKey="Gineikien E" first="E" last="Gineikien">E. Gineikien</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius</wicri:regionArea>
<wicri:noRegion>Vilnius</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hayette, S" sort="Hayette, S" uniqKey="Hayette S" first="S" last="Hayette">S. Hayette</name>
<affiliation wicri:level="1">
<nlm:aff id="aff23">Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite</wicri:regionArea>
<wicri:noRegion>Pierre Bénite</wicri:noRegion>
<wicri:noRegion>Pierre Bénite</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">Medical Genetics Department, Erasme Hospital, Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Medical Genetics Department, Erasme Hospital, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jansson, M" sort="Jansson, M" uniqKey="Jansson M" first="M" last="Jansson">M. Jansson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff26">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johnels, P" sort="Johnels, P" uniqKey="Johnels P" first="P" last="Johnels">P. Johnels</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">Department of Clinical Genetics, University and Regional Laboratories, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Genetics, University and Regional Laboratories, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name>
<affiliation wicri:level="3">
<nlm:aff id="aff28">Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno</wicri:regionArea>
<placeName>
<settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kairisto, V" sort="Kairisto, V" uniqKey="Kairisto V" first="V" last="Kairisto">V. Kairisto</name>
<affiliation wicri:level="3">
<nlm:aff id="aff29">Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku</wicri:regionArea>
<placeName>
<settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kizilors, A" sort="Kizilors, A" uniqKey="Kizilors A" first="A" last="Kizilors">A. Kizilors</name>
<affiliation wicri:level="3">
<nlm:aff id="aff30">Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name>
<affiliation wicri:level="3">
<nlm:aff id="aff31">Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Cancer Research Institute, The Catholic University of Korea, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lange, T" sort="Lange, T" uniqKey="Lange T" first="T" last="Lange">T. Lange</name>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lion, T" sort="Lion, T" uniqKey="Lion T" first="T" last="Lion">T. Lion</name>
<affiliation wicri:level="3">
<nlm:aff id="aff33">Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Polakova, K M" sort="Polakova, K M" uniqKey="Polakova K" first="K M" last="Polakova">K M Polakova</name>
<affiliation wicri:level="3">
<nlm:aff id="aff34">Institute of Hematology and Blood Transfusion, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Institute of Hematology and Blood Transfusion, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Martinelli, G" sort="Martinelli, G" uniqKey="Martinelli G" first="G" last="Martinelli">G. Martinelli</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mccarron, S" sort="Mccarron, S" uniqKey="Mccarron S" first="S" last="Mccarron">S. Mccarron</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Cancer Molecular Diagnostics, St James's Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Merle, P A" sort="Merle, P A" uniqKey="Merle P" first="P A" last="Merle">P A Merle</name>
<affiliation wicri:level="3">
<nlm:aff id="aff37">VU Medical Centre, Department of Haematology, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU Medical Centre, Department of Haematology, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Milner, B" sort="Milner, B" uniqKey="Milner B" first="B" last="Milner">B. Milner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Medical Genetics, NHS-Grampian, Aberdeen, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medical Genetics, NHS-Grampian, Aberdeen</wicri:regionArea>
<wicri:noRegion>Aberdeen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name>
<affiliation wicri:level="3">
<nlm:aff id="aff39">Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Laboratory Medicine, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nagar, M" sort="Nagar, M" uniqKey="Nagar M" first="M" last="Nagar">M. Nagar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Laboratory of Hematology, Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Nickless, G" sort="Nickless, G" uniqKey="Nickless G" first="G" last="Nickless">G. Nickless</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Molecular Oncology Diagnostics Unit, Guy's Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Oncology Diagnostics Unit, Guy's Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nomdedeu, J" sort="Nomdedeu, J" uniqKey="Nomdedeu J" first="J" last="Nomdedéu">J. Nomdedéu</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nymoen, D A" sort="Nymoen, D A" uniqKey="Nymoen D" first="D A" last="Nymoen">D A Nymoen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff43">Division of Pathology, Rikshospital, Oslo University Hospital, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Division of Pathology, Rikshospital, Oslo University Hospital, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Leibundgut, E O" sort="Leibundgut, E O" uniqKey="Leibundgut E" first="E O" last="Leibundgut">E O Leibundgut</name>
<affiliation wicri:level="3">
<nlm:aff id="aff44">Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ozbek, U" sort="Ozbek, U" uniqKey="Ozbek U" first="U" last="Ozbek">U. Ozbek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff45">Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul</wicri:regionArea>
<wicri:noRegion>Istanbul</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana, Slovenia</nlm:aff>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pfeifer, H" sort="Pfeifer, H" uniqKey="Pfeifer H" first="H" last="Pfeifer">H. Pfeifer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff47">Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Preudhomme, C" sort="Preudhomme, C" uniqKey="Preudhomme C" first="C" last="Preudhomme">C. Preudhomme</name>
<affiliation wicri:level="3">
<nlm:aff id="aff48">Laboratoire d'hématologie, CHU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'hématologie, CHU Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Raudsepp, K" sort="Raudsepp, K" uniqKey="Raudsepp K" first="K" last="Raudsepp">K. Raudsepp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff49">United Laboratories of Tartu University Hospitals, Tartu, Estonia</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>United Laboratories of Tartu University Hospitals, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Romeo, G" sort="Romeo, G" uniqKey="Romeo G" first="G" last="Romeo">G. Romeo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff50">Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">Hematology Department, Jagiellonian University, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Hematology Department, Jagiellonian University, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Talmaci, R" sort="Talmaci, R" uniqKey="Talmaci R" first="R" last="Talmaci">R. Talmaci</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest, Romania</nlm:aff>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name>
<affiliation wicri:level="1">
<nlm:aff id="aff53">Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name>
<affiliation wicri:level="3">
<nlm:aff id="aff54">Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Immunology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name>
<affiliation wicri:level="1">
<nlm:aff id="aff55">Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Bristol Genetics Laboratory, Southmead Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wang, L" sort="Wang, L" uniqKey="Wang L" first="L" last="Wang">L. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haematology, Royal Liverpool University Hospital, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wilson, G" sort="Wilson, G" uniqKey="Wilson G" first="G" last="Wilson">G. Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wren, D" sort="Wren, D" uniqKey="Wren D" first="D" last="Wren">D. Wren</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea>
<wicri:noRegion>Sutton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ziermann, J" sort="Ziermann, J" uniqKey="Ziermann J" first="J" last="Ziermann">J. Ziermann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zoi, K" sort="Zoi, K" uniqKey="Zoi K" first="K" last="Zoi">K. Zoi</name>
<affiliation wicri:level="3">
<nlm:aff id="aff62">Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea>
<placeName>
<settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name>
<affiliation wicri:level="3">
<nlm:aff id="aff63">III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schimmel, H" sort="Schimmel, H" uniqKey="Schimmel H" first="H" last="Schimmel">H. Schimmel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Emons, H" sort="Emons, H" uniqKey="Emons H" first="H" last="Emons">H. Emons</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25036192</idno>
<idno type="pmc">4320294</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320294</idno>
<idno type="RBID">PMC:4320294</idno>
<idno type="doi">10.1038/leu.2014.217</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000100</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000100</idno>
<idno type="wicri:Area/Pmc/Curation">000100</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">001774</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001774</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003034</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003034</idno>
<idno type="wicri:Area/PubMed/Curation">002F53</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002F53</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002F53</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002F53</idno>
<idno type="wicri:Area/Ncbi/Merge">001C33</idno>
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<idno type="wicri:doubleKey">0887-6924:2014:White H:a:certified:plasmid</idno>
<idno type="wicri:Area/Main/Merge">003D08</idno>
<idno type="wicri:Area/Main/Curation">003C57</idno>
<idno type="wicri:Area/Main/Exploration">003C57</idno>
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<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">A certified plasmid reference material for the standardisation of
<italic>BCR–ABL1</italic>
mRNA quantification by real-time quantitative PCR</title>
<author>
<name sortKey="White, H" sort="White, H" uniqKey="White H" first="H" last="White">H. White</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deprez, L" sort="Deprez, L" uniqKey="Deprez L" first="L" last="Deprez">L. Deprez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Corbisier, P" sort="Corbisier, P" uniqKey="Corbisier P" first="P" last="Corbisier">P. Corbisier</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hall, V" sort="Hall, V" uniqKey="Hall V" first="V" last="Hall">V. Hall</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lin, F" sort="Lin, F" uniqKey="Lin F" first="F" last="Lin">F. Lin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mazoua, S" sort="Mazoua, S" uniqKey="Mazoua S" first="S" last="Mazoua">S. Mazoua</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trapmann, S" sort="Trapmann, S" uniqKey="Trapmann S" first="S" last="Trapmann">S. Trapmann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Aggerholm, A" sort="Aggerholm, A" uniqKey="Aggerholm A" first="A" last="Aggerholm">A. Aggerholm</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Department of Haematology, Aarhus University Hospital</institution>
, Aarhus,
<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Andrikovics, H" sort="Andrikovics, H" uniqKey="Andrikovics H" first="H" last="Andrikovics">H. Andrikovics</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Hungarian National Blood Transfusion Service</institution>
, Budapest,
<country>Hungary</country>
</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Akiki, S" sort="Akiki, S" uniqKey="Akiki S" first="S" last="Akiki">S. Akiki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust</institution>
, Birmingham,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Barbany, G" sort="Barbany, G" uniqKey="Barbany G" first="G" last="Barbany">G. Barbany</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Molecular Medicine and Surgery, Clinical Genetics Karolinska Institutet</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boeckx, N" sort="Boeckx, N" uniqKey="Boeckx N" first="N" last="Boeckx">N. Boeckx</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>Department of Laboratory Medicine</institution>
, UZ Leuven,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Department of Oncology, KU</institution>
Leuven,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bench, A" sort="Bench, A" uniqKey="Bench A" first="A" last="Bench">A. Bench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Molecular Malignancy Laboratory and Haemato-Oncology Diagnostic Service, Cambridge University Hospitals NHS Foundation Trust</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Catherwood, M" sort="Catherwood, M" uniqKey="Catherwood M" first="M" last="Catherwood">M. Catherwood</name>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Haematology Department, Belfast City Hospital</institution>
, Belfast,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cayuela, J M" sort="Cayuela, J M" uniqKey="Cayuela J" first="J-M" last="Cayuela">J-M Cayuela</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Haematology Laboratory and EA3518, University Hospital Saint-Louis, AP-HP, University Paris Diderot</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chudleigh, S" sort="Chudleigh, S" uniqKey="Chudleigh S" first="S" last="Chudleigh">S. Chudleigh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Department of Molecular Haematology, Yorkhill NHS Trust</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Clench, T" sort="Clench, T" uniqKey="Clench T" first="T" last="Clench">T. Clench</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">Molecular Haematology, Bristol Royal Infirmary, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Haematology, Bristol Royal Infirmary, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Colomer, D" sort="Colomer, D" uniqKey="Colomer D" first="D" last="Colomer">D. Colomer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff15">Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hematopathology Unit, Hospital Clinic, IDIBAPS, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Daraio, F" sort="Daraio, F" uniqKey="Daraio F" first="F" last="Daraio">F. Daraio</name>
<affiliation wicri:level="3">
<nlm:aff id="aff16">Department of Clinical and Biological Science, University of Turin, Turin, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical and Biological Science, University of Turin, Turin</wicri:regionArea>
<placeName>
<settlement type="city">Turin</settlement>
<region type="région" nuts="2">Piémont</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dulucq, S" sort="Dulucq, S" uniqKey="Dulucq S" first="S" last="Dulucq">S. Dulucq</name>
<affiliation wicri:level="3">
<nlm:aff id="aff17">Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire Hematologie, CHU Bordeaux, Hematopoiese Leucemique et Cibles Therapeutiques, INSERM U1035, Universite Bordeaux, Bordeaux</wicri:regionArea>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Farrugia, J" sort="Farrugia, J" uniqKey="Farrugia J" first="J" last="Farrugia">J. Farrugia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">Combined Laboratories, Derriford Hospital, Plymouth, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Combined Laboratories, Derriford Hospital, Plymouth</wicri:regionArea>
<wicri:noRegion>Plymouth</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fletcher, L" sort="Fletcher, L" uniqKey="Fletcher L" first="L" last="Fletcher">L. Fletcher</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, SA</wicri:regionArea>
<wicri:noRegion>SA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Foroni, L" sort="Foroni, L" uniqKey="Foroni L" first="L" last="Foroni">L. Foroni</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ganderton, R" sort="Ganderton, R" uniqKey="Ganderton R" first="R" last="Ganderton">R. Ganderton</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Pathology, University Hospitals Southampton NHS Foundation Trust, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gerrard, G" sort="Gerrard, G" uniqKey="Gerrard G" first="G" last="Gerrard">G. Gerrard</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial Molecular Pathology, Centre for Haematology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gineikien, E" sort="Gineikien, E" uniqKey="Gineikien E" first="E" last="Gineikien">E. Gineikien</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius</wicri:regionArea>
<wicri:noRegion>Vilnius</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hayette, S" sort="Hayette, S" uniqKey="Hayette S" first="S" last="Hayette">S. Hayette</name>
<affiliation wicri:level="1">
<nlm:aff id="aff23">Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Molecular Biology and UMR5239, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre Bénite</wicri:regionArea>
<wicri:noRegion>Pierre Bénite</wicri:noRegion>
<wicri:noRegion>Pierre Bénite</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="El Housni, H" sort="El Housni, H" uniqKey="El Housni H" first="H" last="El Housni">H. El Housni</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">Medical Genetics Department, Erasme Hospital, Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Medical Genetics Department, Erasme Hospital, Brussels</wicri:regionArea>
<placeName>
<settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Izzo, B" sort="Izzo, B" uniqKey="Izzo B" first="B" last="Izzo">B. Izzo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff25">Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Medicine and Surgery, University ‘Federico II' of Naples, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jansson, M" sort="Jansson, M" uniqKey="Jansson M" first="M" last="Jansson">M. Jansson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff26">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johnels, P" sort="Johnels, P" uniqKey="Johnels P" first="P" last="Johnels">P. Johnels</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">Department of Clinical Genetics, University and Regional Laboratories, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Genetics, University and Regional Laboratories, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jurcek, T" sort="Jurcek, T" uniqKey="Jurcek T" first="T" last="Jurcek">T. Jurcek</name>
<affiliation wicri:level="3">
<nlm:aff id="aff28">Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Internal Medicine-Hematology and Oncology, Masaryk University and University Hospital Brno, Brno</wicri:regionArea>
<placeName>
<settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kairisto, V" sort="Kairisto, V" uniqKey="Kairisto V" first="V" last="Kairisto">V. Kairisto</name>
<affiliation wicri:level="3">
<nlm:aff id="aff29">Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku University Hospital, TYKSLAB, Laboratory of Molecular Genetics, Turku</wicri:regionArea>
<placeName>
<settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kizilors, A" sort="Kizilors, A" uniqKey="Kizilors A" first="A" last="Kizilors">A. Kizilors</name>
<affiliation wicri:level="3">
<nlm:aff id="aff30">Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Laboratory for Molecular Haemato-Oncology, Kings College Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kim, D W" sort="Kim, D W" uniqKey="Kim D" first="D-W" last="Kim">D-W Kim</name>
<affiliation wicri:level="3">
<nlm:aff id="aff31">Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Cancer Research Institute, The Catholic University of Korea, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lange, T" sort="Lange, T" uniqKey="Lange T" first="T" last="Lange">T. Lange</name>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Abteilung für Hämatologie und internistische Onkologie, Universität Leipzig, Leipzig</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lion, T" sort="Lion, T" uniqKey="Lion T" first="T" last="Lion">T. Lion</name>
<affiliation wicri:level="3">
<nlm:aff id="aff33">Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Children's Cancer Research Institute/LabDia Labordiagnostik and Medical University, Vienna</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Polakova, K M" sort="Polakova, K M" uniqKey="Polakova K" first="K M" last="Polakova">K M Polakova</name>
<affiliation wicri:level="3">
<nlm:aff id="aff34">Institute of Hematology and Blood Transfusion, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Institute of Hematology and Blood Transfusion, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Martinelli, G" sort="Martinelli, G" uniqKey="Martinelli G" first="G" last="Martinelli">G. Martinelli</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mccarron, S" sort="Mccarron, S" uniqKey="Mccarron S" first="S" last="Mccarron">S. Mccarron</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">Cancer Molecular Diagnostics, St James's Hospital, Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Cancer Molecular Diagnostics, St James's Hospital, Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Merle, P A" sort="Merle, P A" uniqKey="Merle P" first="P A" last="Merle">P A Merle</name>
<affiliation wicri:level="3">
<nlm:aff id="aff37">VU Medical Centre, Department of Haematology, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU Medical Centre, Department of Haematology, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Milner, B" sort="Milner, B" uniqKey="Milner B" first="B" last="Milner">B. Milner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Medical Genetics, NHS-Grampian, Aberdeen, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Medical Genetics, NHS-Grampian, Aberdeen</wicri:regionArea>
<wicri:noRegion>Aberdeen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mitterbauer Hohendanner, G" sort="Mitterbauer Hohendanner, G" uniqKey="Mitterbauer Hohendanner G" first="G" last="Mitterbauer-Hohendanner">G. Mitterbauer-Hohendanner</name>
<affiliation wicri:level="3">
<nlm:aff id="aff39">Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Laboratory Medicine, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName>
<settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nagar, M" sort="Nagar, M" uniqKey="Nagar M" first="M" last="Nagar">M. Nagar</name>
<affiliation wicri:level="1">
<nlm:aff id="aff40">Laboratory of Hematology, Sheba Medical Center, Tel Hashomer, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Laboratory of Hematology, Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Nickless, G" sort="Nickless, G" uniqKey="Nickless G" first="G" last="Nickless">G. Nickless</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Molecular Oncology Diagnostics Unit, Guy's Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Oncology Diagnostics Unit, Guy's Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nomdedeu, J" sort="Nomdedeu, J" uniqKey="Nomdedeu J" first="J" last="Nomdedéu">J. Nomdedéu</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Lab Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea>
<placeName>
<settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nymoen, D A" sort="Nymoen, D A" uniqKey="Nymoen D" first="D A" last="Nymoen">D A Nymoen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff43">Division of Pathology, Rikshospital, Oslo University Hospital, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Division of Pathology, Rikshospital, Oslo University Hospital, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Leibundgut, E O" sort="Leibundgut, E O" uniqKey="Leibundgut E" first="E O" last="Leibundgut">E O Leibundgut</name>
<affiliation wicri:level="3">
<nlm:aff id="aff44">Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, Department of Hematology, University Hospital Bern, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ozbek, U" sort="Ozbek, U" uniqKey="Ozbek U" first="U" last="Ozbek">U. Ozbek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff45">Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey</nlm:aff>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Istanbul</wicri:regionArea>
<wicri:noRegion>Istanbul</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Paji, T" sort="Paji, T" uniqKey="Paji T" first="T" last="Paji">T. Paji</name>
<affiliation wicri:level="1">
<nlm:aff id="aff46">Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana, Slovenia</nlm:aff>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Specialized Haematology Laboratory, Division of Internal Medicine, Department of Haematology, University Medical Centre, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pfeifer, H" sort="Pfeifer, H" uniqKey="Pfeifer H" first="H" last="Pfeifer">H. Pfeifer</name>
<affiliation wicri:level="3">
<nlm:aff id="aff47">Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine, Hematology/Oncology, Goethe University, Frankfurt</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Preudhomme, C" sort="Preudhomme, C" uniqKey="Preudhomme C" first="C" last="Preudhomme">C. Preudhomme</name>
<affiliation wicri:level="3">
<nlm:aff id="aff48">Laboratoire d'hématologie, CHU Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'hématologie, CHU Lille, Lille</wicri:regionArea>
<placeName>
<region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Raudsepp, K" sort="Raudsepp, K" uniqKey="Raudsepp K" first="K" last="Raudsepp">K. Raudsepp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff49">United Laboratories of Tartu University Hospitals, Tartu, Estonia</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea>United Laboratories of Tartu University Hospitals, Tartu</wicri:regionArea>
<wicri:noRegion>Tartu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Romeo, G" sort="Romeo, G" uniqKey="Romeo G" first="G" last="Romeo">G. Romeo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff50">Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Haematology Laboratory, PathWest Laboratory Medicine, Royal Perth Hospital, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sacha, T" sort="Sacha, T" uniqKey="Sacha T" first="T" last="Sacha">T. Sacha</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">Hematology Department, Jagiellonian University, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Hematology Department, Jagiellonian University, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Talmaci, R" sort="Talmaci, R" uniqKey="Talmaci R" first="R" last="Talmaci">R. Talmaci</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest, Romania</nlm:aff>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Hematology Department, Fundeni Clinical Institute, University of Medicine and Pharmacy ‘Carol Davila', Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Touloumenidou, T" sort="Touloumenidou, T" uniqKey="Touloumenidou T" first="T" last="Touloumenidou">T. Touloumenidou</name>
<affiliation wicri:level="1">
<nlm:aff id="aff53">Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Der Velden, V H J" sort="Van Der Velden, V H J" uniqKey="Van Der Velden V" first="V H J" last="Van Der Velden">V H J. Van Der Velden</name>
<affiliation wicri:level="3">
<nlm:aff id="aff54">Department of Immunology, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Immunology, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waits, P" sort="Waits, P" uniqKey="Waits P" first="P" last="Waits">P. Waits</name>
<affiliation wicri:level="1">
<nlm:aff id="aff55">Bristol Genetics Laboratory, Southmead Hospital, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Bristol Genetics Laboratory, Southmead Hospital, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wang, L" sort="Wang, L" uniqKey="Wang L" first="L" last="Wang">L. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haematology, Royal Liverpool University Hospital, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wilkinson, E" sort="Wilkinson, E" uniqKey="Wilkinson E" first="E" last="Wilkinson">E. Wilkinson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>HMDS, Leeds Institute of Oncology, St James's University Hospital, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wilson, G" sort="Wilson, G" uniqKey="Wilson G" first="G" last="Wilson">G. Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wren, D" sort="Wren, D" uniqKey="Wren D" first="D" last="Wren">D. Wren</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Molecular Diagnostics, The Royal Marsden NHS Foundation Trust, Sutton</wicri:regionArea>
<wicri:noRegion>Sutton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zadro, R" sort="Zadro, R" uniqKey="Zadro R" first="R" last="Zadro">R. Zadro</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Laboratory Diagnostics, Clinical Hospital Center, Zagreb University School of Medicine, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ziermann, J" sort="Ziermann, J" uniqKey="Ziermann J" first="J" last="Ziermann">J. Ziermann</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zoi, K" sort="Zoi, K" uniqKey="Zoi K" first="K" last="Zoi">K. Zoi</name>
<affiliation wicri:level="3">
<nlm:aff id="aff62">Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens</wicri:regionArea>
<placeName>
<settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Muller, M C" sort="Muller, M C" uniqKey="Muller M" first="M C" last="Müller">M C Müller</name>
<affiliation wicri:level="3">
<nlm:aff id="aff63">III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>III. Medizinische Klinik, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hochhaus, A" sort="Hochhaus, A" uniqKey="Hochhaus A" first="A" last="Hochhaus">A. Hochhaus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">Department of Hematology/Oncology, Jena University Hospital, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Hematology/Oncology, Jena University Hospital, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schimmel, H" sort="Schimmel, H" uniqKey="Schimmel H" first="H" last="Schimmel">H. Schimmel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Cross, N C P" sort="Cross, N C P" uniqKey="Cross N" first="N C P" last="Cross">N C P. Cross</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>National Genetics Reference Laboratory (Wessex), Salisbury District Hospital</institution>
, Salisbury,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Faculty of Medicine, University of Southampton</institution>
, Southampton,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Emons, H" sort="Emons, H" uniqKey="Emons H" first="H" last="Emons">H. Emons</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>European Commission, Joint Research Centre, Institute for Reference Materials and Measurements</institution>
, Geel,
<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Leukemia</title>
<idno type="ISSN">0887-6924</idno>
<idno type="eISSN">1476-5551</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Calibration</term>
<term>Cloning, Molecular</term>
<term>DNA</term>
<term>Escherichia coli Proteins (genetics)</term>
<term>Fusion Proteins, bcr-abl (genetics)</term>
<term>Fusion Proteins, bcr-abl (metabolism)</term>
<term>Gene Dosage</term>
<term>Humans</term>
<term>Membrane Transport Proteins (genetics)</term>
<term>Plasmids (genetics)</term>
<term>Proto-Oncogene Proteins c-bcr (genetics)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Real-Time Polymerase Chain Reaction (standards)</term>
<term>Reference Standards</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>ADN</term>
<term>ARN messager (métabolisme)</term>
<term>Calibrage</term>
<term>Clonage moléculaire</term>
<term>Dosage génique</term>
<term>Humains</term>
<term>Normes de référence</term>
<term>Plasmides (génétique)</term>
<term>Protéines Escherichia coli (génétique)</term>
<term>Protéines de fusion bcr-abl (génétique)</term>
<term>Protéines de fusion bcr-abl (métabolisme)</term>
<term>Protéines de transport membranaire (génétique)</term>
<term>Protéines proto-oncogènes c-bcr (génétique)</term>
<term>Réaction de polymérisation en chaine en temps réel (normes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Escherichia coli Proteins</term>
<term>Fusion Proteins, bcr-abl</term>
<term>Membrane Transport Proteins</term>
<term>Proto-Oncogene Proteins c-bcr</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Fusion Proteins, bcr-abl</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Plasmids</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Plasmides</term>
<term>Protéines Escherichia coli</term>
<term>Protéines de fusion bcr-abl</term>
<term>Protéines de transport membranaire</term>
<term>Protéines proto-oncogènes c-bcr</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>ARN messager</term>
<term>Protéines de fusion bcr-abl</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr">
<term>Réaction de polymérisation en chaine en temps réel</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en">
<term>Real-Time Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Calibration</term>
<term>Cloning, Molecular</term>
<term>Gene Dosage</term>
<term>Humans</term>
<term>Reference Standards</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>ADN</term>
<term>Calibrage</term>
<term>Clonage moléculaire</term>
<term>Dosage génique</term>
<term>Humains</term>
<term>Normes de référence</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>Serial quantification of
<italic>BCR–ABL1</italic>
mRNA is an important therapeutic indicator in chronic myeloid leukaemia, but there is a substantial variation in results reported by different laboratories. To improve comparability, an internationally accepted plasmid certified reference material (CRM) was developed according to ISO Guide 34:2009. Fragments of
<italic>BCR–ABL1</italic>
(e14a2 mRNA fusion)
<italic>, BCR</italic>
and
<italic>GUSB</italic>
transcripts were amplified and cloned into pUC18 to yield plasmid pIRMM0099. Six different linearised plasmid solutions were produced with the following copy number concentrations, assigned by digital PCR, and expanded uncertainties: 1.08±0.13 × 10
<sup>6</sup>
, 1.08±0.11 × 10
<sup>5</sup>
, 1.03±0.10 × 10
<sup>4</sup>
, 1.02±0.09 × 10
<sup>3</sup>
, 1.04±0.10 × 10
<sup>2</sup>
and 10.0±1.5 copies/μl. The certification of the material for the number of specific DNA fragments per plasmid, copy number concentration of the plasmid solutions and the assessment of inter-unit heterogeneity and stability were performed according to ISO Guide 35:2006. Two suitability studies performed by 63
<italic>BCR–ABL1</italic>
testing laboratories demonstrated that this set of 6 plasmid CRMs can help to standardise a number of measured transcripts of e14a2
<italic>BCR–ABL1</italic>
and three control genes (
<italic>ABL1, BCR</italic>
and
<italic>GUSB</italic>
). The set of six plasmid CRMs is distributed worldwide by the Institute for Reference Materials and Measurements (Belgium) and its authorised distributors (
<ext-link ext-link-type="uri" xlink:href="https://ec.europa.eu/jrc/en/reference-materials/catalogue/">https://ec.europa.eu/jrc/en/reference-materials/catalogue/</ext-link>
; CRM code ERM-AD623a-f).</p>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
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<li>Allemagne</li>
<li>Australie</li>
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<li>Corée du Sud</li>
<li>Croatie</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Estonie</li>
<li>Finlande</li>
<li>France</li>
<li>Grèce</li>
<li>Hongrie</li>
<li>Irlande (pays)</li>
<li>Israël</li>
<li>Italie</li>
<li>Lituanie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Roumanie</li>
<li>Royaume-Uni</li>
<li>République tchèque</li>
<li>Slovénie</li>
<li>Suisse</li>
<li>Suède</li>
<li>Turquie</li>
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<li>Angleterre</li>
<li>Aquitaine</li>
<li>Attique (région)</li>
<li>Bade-Wurtemberg</li>
<li>Bohême centrale</li>
<li>Canton de Berne</li>
<li>Catalogne</li>
<li>District de Darmstadt</li>
<li>District de Karlsruhe</li>
<li>District de Leipzig</li>
<li>East Middle Sweden</li>
<li>Finlande occidentale</li>
<li>Grand Londres</li>
<li>Hauts-de-France</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Moravie</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Piémont</li>
<li>Région capitale de Séoul</li>
<li>Région de Bruxelles-Capitale</li>
<li>Saxe (Land)</li>
<li>Svealand</li>
<li>Vienne (Autriche)</li>
<li>Østlandet</li>
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<li>Amsterdam</li>
<li>Athènes</li>
<li>Barcelone</li>
<li>Berne</li>
<li>Bordeaux</li>
<li>Brno</li>
<li>Bruxelles</li>
<li>Francfort-sur-le-Main</li>
<li>Leipzig</li>
<li>Lille</li>
<li>Londres</li>
<li>Mannheim</li>
<li>Oslo</li>
<li>Prague</li>
<li>Rotterdam</li>
<li>Séoul</li>
<li>Turin</li>
<li>Turku</li>
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<li>Vienne (Autriche)</li>
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